Langmuir publication – Femtomolar Detection of Spermidine

Noble metals such as gold and silver behave contrastively at nano-dimensions. While silver intrinsically enhances the luminescence of a fluorophore (a fluorescent chemical compound that can re-emit light upon light excitation), gold quenches the same.

In an attempt to overcome this inevitable loss in plasmon-coupled emission platform, Dr. Sai Sathish Ramamurthy, Asst. Professor, STAR Labs and Dr. S Prathap Chandran, Asst. Professor, Dept. of Chemistry, SSSIHL have come up with novel hybridized plasmon engineering methodology.

The research group have innovated a translation application using a cell phone camera to detect spermidine in aqueous samples. Further research could help realize the detection of spermidine in biological specimens as well.

Spermidine is an indispensable natural polyamine compound – found in ribosomes & living tissues, having various metabolic functions within organisms, required for maintaining cellular homeostasis in every living organism. Apart from exhibiting anti-inflammatory and antioxidant properties, this molecule significantly affects several biological processes including tissue regeneration, cardioprotective and neuroprotective effects, regulation of translation, cell growth and proliferation, DNA and RNA stabilization, and enzymatic modulation to name a few.

The group have published a paper entitled: Femtomolar Detection of Spermidine using Au Decorated SiO Nanohybrid on Plasmon-Coupled Extended Cavity Nanointerface: A Smartphone based Fluorescence Dequenching approach.

Read the paper in ACS Langmuir: https://pubs.acs.org/doi/abs/10.1021/acs.langmuir.9b03869

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