Identifying the Issue
- Cancer is the most feared and deadly disease worldwide.
- Treatment of cancer is limited because of the limited functional molecules available.
Objective of the Research
To synthesize novel amide derivatives of arjunolic acid and to study their anti-cancer properties.
Who should read this?
Research community working in anti-cancer drug development, medicinal chemists, and pharmaceutical industry
Solution
Development of nontoxic small molecules, based on natural product scaffolds, with high therapeutic effect and selectivity.
Key Features and Benefits
- The synthesized amides of arjunolic acid show promising anti-cancer properties.
- Arrest the cell cycle of cancer cells at the G0/G1
- These compounds have improved anti-cancer properties than arjunolic acid.
Impact
- Potent compounds from this study have better anti-cancer properties than the parent compound arjunolic acid.
- Effective against colon cancer.
- Animal models also prove that these derivatives can inhibit the growth of colon cancer.
- Lead compounds from this study offer new and more effective treatment options for colon cancer.
- This work has been published on the cover page of Current Medicinal Chemistry
Team
Manohar Bhujel, Shalu Kaloniya, Lakshminath Sripada, Dolly Jain, Avinash Bajaj, Nageswara Rao Golakoti. *
Title of paper: “Amide Derivative of Arjunolic Acid TA-1,4-BiP Enhances ROS mediated Apoptosis in Colorectal Cancer Cells”
Read Paper Here: http://dx.doi.org/10.2174/0109298673348718250109142630