Point of Care Devices for Clinical Use
As a part of the ongoing projects on perinatal depression, neonatal jaundice, early detection of cardiac malfunction and dengue detection, more than 700 patients from Sri Sathya Sai General Hospital (SSSGH), Prasanthi Nilayam, Sri Sathya Sai Institute of Higher Medical Sciences (SSSIHMS), Prasanthigram and SSSIHMS, Whitefield have been enrolled. The blood, saliva and urine samples from these patients were collected after obtaining informed consent. These samples were processed and stored appropriately. These samples were analysed using standard hospital protocol/equipment and gold standard- HPLC to know the actual value to be compared with that from our proposed devices.
Dengue and heart disease detection devices underwent testing of their alpha models. The feedback was noted and appropriate modifications have been implemented in the fabrication of the beta version. The neonatal device was deployed at SSSGH, Prasanthi Nilayam for field trials. The device for monitoring depression is under fabrication and is planned to be deployed for field trials by the end of this year. In addition, new novel materials for SPCE emission enhancements were studied and the mobile phone-SPCE platform was optimized for the detection of Tannic acid in water sources. Simple, candle soot-based fractal nano carbon islands were coated and shown to be better spacer layers than other nanomaterials that are less eco-friendly due to their synthesis protocol.
Work on novel materials, such as photonic crystals and soret nanoparticle assemblies for the detection of femtomolar aluminum ions, spermidine, iodide & glutathione and zeptomolar cortisol, is also underway.