SSSIHL

logologologo
  • About Us
    • Revered Founder Chancellor
    • A modern Gurukula
    • Vision, Mission & Philosophy
    • Educare
    • Governance
    • University Structure
    • History & Timeline
    • Campuses
    • Facilities
    • Contact Us
  • Integral Education
    • Residential Character
    • Devotional & Cultural Dimensions
    • Intellectual Dimension
    • Physical & Service Dimensions
    • Residential Teachers
    • Community Service
    • Special Annual Events
  • Academics
    • Key Contributing Factors
    • Programmes for Admissions
    • Departments
    • Faculty
    • Academic Calendar 2022/23
    • Adjunct & Visiting Faculty
    • News & Events
  • Research
    • Overview
    • Research Spotlight
    • Research Areas
    • Research Projects
    • Research Publications
    • CRIF
    • CRL
  • Admissions
    • Programmes for Admissions
    • Application Guide
    • Apply Online
    • Dates & Deadlines*
    • Admissions Downloads
  • Resources
    • Accreditation
    • Publications
    • Examinations Services
    • Recruitment
    • Academic Calendar 2022/23
    • Student Support
    • Get Involved
    • Sister Organizations
    • Alumni
  • News & Events
    • Academic
    • Research
    • Press Releases
    • Integral Education
  • About Us
    • Revered Founder Chancellor
    • A modern Gurukula
    • Vision, Mission & Philosophy
    • Educare
    • Governance
    • University Structure
    • History & Timeline
    • Campuses
    • Facilities
    • Contact Us
  • Integral Education
    • Residential Character
    • Devotional & Cultural Dimensions
    • Intellectual Dimension
    • Physical & Service Dimensions
    • Residential Teachers
    • Community Service
    • Special Annual Events
  • Academics
    • Key Contributing Factors
    • Programmes for Admissions
    • Departments
    • Faculty
    • Academic Calendar 2022/23
    • Adjunct & Visiting Faculty
    • News & Events
  • Research
    • Overview
    • Research Spotlight
    • Research Areas
    • Research Projects
    • Research Publications
    • CRIF
    • CRL
  • Admissions
    • Programmes for Admissions
    • Application Guide
    • Apply Online
    • Dates & Deadlines*
    • Admissions Downloads
  • Resources
    • Accreditation
    • Publications
    • Examinations Services
    • Recruitment
    • Academic Calendar 2022/23
    • Student Support
    • Get Involved
    • Sister Organizations
    • Alumni
  • News & Events
    • Academic
    • Research
    • Press Releases
    • Integral Education

SSSIHL

logologologo
  • About Us
    • Revered Founder Chancellor
    • A modern Gurukula
    • Vision, Mission & Philosophy
    • Educare
    • Governance
    • University Structure
    • History & Timeline
    • Campuses
    • Facilities
    • Contact Us
  • Integral Education
    • Residential Character
    • Devotional & Cultural Dimensions
    • Intellectual Dimension
    • Physical & Service Dimensions
    • Residential Teachers
    • Community Service
    • Special Annual Events
  • Academics
    • Key Contributing Factors
    • Programmes for Admissions
    • Departments
    • Faculty
    • Academic Calendar 2022/23
    • Adjunct & Visiting Faculty
    • News & Events
  • Research
    • Overview
    • Research Spotlight
    • Research Areas
    • Research Projects
    • Research Publications
    • CRIF
    • CRL
  • Admissions
    • Programmes for Admissions
    • Application Guide
    • Apply Online
    • Dates & Deadlines*
    • Admissions Downloads
  • Resources
    • Accreditation
    • Publications
    • Examinations Services
    • Recruitment
    • Academic Calendar 2022/23
    • Student Support
    • Get Involved
    • Sister Organizations
    • Alumni
  • News & Events
    • Academic
    • Research
    • Press Releases
    • Integral Education
  • About Us
    • Revered Founder Chancellor
    • A modern Gurukula
    • Vision, Mission & Philosophy
    • Educare
    • Governance
    • University Structure
    • History & Timeline
    • Campuses
    • Facilities
    • Contact Us
  • Integral Education
    • Residential Character
    • Devotional & Cultural Dimensions
    • Intellectual Dimension
    • Physical & Service Dimensions
    • Residential Teachers
    • Community Service
    • Special Annual Events
  • Academics
    • Key Contributing Factors
    • Programmes for Admissions
    • Departments
    • Faculty
    • Academic Calendar 2022/23
    • Adjunct & Visiting Faculty
    • News & Events
  • Research
    • Overview
    • Research Spotlight
    • Research Areas
    • Research Projects
    • Research Publications
    • CRIF
    • CRL
  • Admissions
    • Programmes for Admissions
    • Application Guide
    • Apply Online
    • Dates & Deadlines*
    • Admissions Downloads
  • Resources
    • Accreditation
    • Publications
    • Examinations Services
    • Recruitment
    • Academic Calendar 2022/23
    • Student Support
    • Get Involved
    • Sister Organizations
    • Alumni
  • News & Events
    • Academic
    • Research
    • Press Releases
    • Integral Education
16/12/2021 by SSSIHL Academic, Research

B-T hybrids with a Potential to Inhibit the Viral Replication of SARS -CoV-2

Identifying the Issue

COVID-19 is the largest global pandemic currently and it has emerged as the deadliest infection of the century. It’s still critical to find novel compounds that can inhibit viral replication, in turn reducing the pace of infection.

Objective of the Research

  • To design and synthesise benzoxazole-thiazolidinone hybrids (B-T hybrids) using a facile synthetic route.
  • To analyse the inhibitory potential of designed B-T hybrids against the SARS-CoV-2 proteases using an in-silico approach.

Who should read this?

COVID-19 Researchers, Medicinal Chemists and Pharmaceutical Industry.

Solution

Hybrid molecules represent a relatively recent area in drug research with promising results.

The two scaffolds (benzoxazole and thiazolidinone) exhibit a wide spectrum of pharmacological activities and showed antiviral efficacy (both in vitro and in vivo) against a variety of viruses.

The hybrids derived from these two scaffolds share a similarity (structurally) with some of the active compounds screened in vitro against SARS-CoV-2.

This motivated us to screen the benzoxazole–thiazolidinone hybrids as SARS-CoV-2 protease inhibitors. In order to achieve this, a combination of docking, dynamics, and free energy studies were employed in this study.

 

Key Features and Benefits

  • Established the key interactions between the B-T hybrids and SARS-CoV-2 proteases.
  • A simple four-step synthetic procedure was developed to synthesise the B-T hybrids.
  • Identifying a novel compound (MBT9) that could act as an allosteric inhibitor of PLp, thus inhibits viral replication, in turn reducing the pace of infection.

Impact

  • This study is related to the COVID-19 research and contributes to the understanding of SARS-CoV-2.
  • The in-vivo and in-vitro studies could be carried out to further evaluate the therapeutic potential of the proposed ligands.
  • The potential of the B-T hybrids as covalent binders to 3CLp can also be explored, as the conjugate amide group present in the thiazolidinone scaffold of the molecule can serve as a Michael acceptor.

Team

Vijay Sai Krishna Cheerala, Research Scholar, Department of Chemistry, Brindavan Campus, SSSIHL

Prasanth Ghanta, Research Scholar, Department of Biosciences, Prasanthi Nilayam Campus, SSSIHL

Prof. C N Sundaresan, Professor (Hon.), Department of Chemistry, Brindavan Campus, SSSIHL

Paper Published in: RSC Advances (Royal Society of Chemistry)

Title: Design, synthesis and in silico screening of benzoxazole–thiazolidinone hybrids as potential inhibitors of SARS-CoV-2 proteases

Read Paper Here: https://pubs.rsc.org/en/content/articlelanding/2021/ra/d1ra07504g

Academic Year 2021/22 Biosciences Chemistry COVID-19 Research

Related Posts

Novel method for simultaneous analysis of endocrine disruptors and polycyclic aromatic hydrocarbons bound to ambient fine particulate matter

10/10/2022
Read More

IAEA Conference Presentation, Vienna

10/12/2018
Read More

B-T hybrids with a Potential to Inhibit the Viral Replication of SARS -CoV-2

16/12/2021
Read More

B.B.A. Students – Industrial Visit – Feb 2020

17/02/2020
Read More
SSSIHL Annual Convocation – 2021Previous Post
Madurai Shanmukhavadivu Subbulakshmi Sangeet Samman 2021 conferred on Sri Mahesh VarmaNext Post
logo

Connect with Us

Contact UsNews and EventsResourcesGet Involved

Quick Links

  • Academic Calendar
  • Recruitment
  • Publications
  • Annual Report
  • Accreditation
  • Examinations Services
  • Alumni
  • Facilities

Admissions

  • Find a Programme
  • Application Guide
  • Dates & Deadlines*
  • Admissions Downloads
  • Admissions Prospectus

Academics & Research

  • Faculty
  • Research Areas
  • Research Projects
  • Central Research Instruments Facility
About this SiteSite Map
© 2020 Sri Sathya Sai Institute of Higher Learning (Deemed to be University)