Identifying the Issue
Terminalia arjuna and its major constituents are well known for their medicinal properties for various ailments. However, a comprehensive review of the complete literature was not available.
Objective of the Research
To provide all the scientific information available for Terminalia arjuna and arjunolic acid till date as a comprehensive review.
Who should read this?
Faculty, research scholars, natural product chemists, pharmaceutical industries, and students of Medicinal and Organic chemistry
Solution
Plants have long been a primary source of natural products for medicine. Terminalia arjuna, a deciduous tree native to the Indian subcontinent, is renowned for its diverse biological properties, such as anticancer, anti-diabetic, and cardioprotective effects. Various parts of this tree have been used to treat numerous ailments such as cancer, diabetes, inflammation, and microbial infections, as mentioned in ancient medicinal texts such as Ayurveda and Charaka Samhita. Arjunolic acid, a pentacyclic triterpene, is a major constituent of T. arjuna, and exhibits a plethora of biological properties such as anti-cancer, anti-diabetic, anti-inflammatory, and antioxidant activities. Diverse research groups have utilized arjunolic acid as a template for synthesizing various semi-synthetic derivatives, which have been evaluated for their anti-cancer, anti-diabetic, and antioxidant properties. This review comprehensively compiles and discusses the literature related to T. arjuna, arjunolic acid and its derivatives, focusing on their medicinal properties and the mechanism of their biological activities.
Key Features and Benefits
We report the comprehensive and through review on works that have been done so far on Terminalia arjuna and arjunolic acid by various research groups. Since there has been quite an interest in arjunolic acid recently, this review will definitely help those researchers to understand the literature better and can serve as a guide for further research in this area.
Impact
- This review gives full knowledge about the work done on T.arjuna and arjunolic acid.
- The potential of these will be known from this review. This knowledge will also help to know the scope for further research on T.arjuna and arjunolic acid.
Team
Manohar Bhujel, Sai Giridhar Sarma Kandanur, Lakshminath Sripada, and Nageswara Rao Golakoti *
Title of paper: “A comprehensive review of the medicinal properties of Terminalia arjuna and its major constituent arjunolic acid: a natural product source for new drug leads”
Read Paper Here: https://doi.org/10.1039/D6RA02419J
